Brofaromine溴法罗明,63638-91-5

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Brofaromine

CAS No. : 63638-91-5

MCE 国际站：Brofaromine

产品活性：Brofaromine (CGP 11305A) 是一种单胺氧化酶 (MAO) 抑制剂，抑制 MAO-A，IC₅₀ 为 0.2 μM。

研究领域：Neuronal Signaling

作用靶点：Monoamine Oxidase

In Vitro: In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC₅₀ is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC₅₀ range of Brofaromine is 0.01 μM to 0.1 μM.

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