Fradafiban夫雷非班,148396-36-5

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Fradafiban

CAS No. : 148396-36-5

MCE 国际站：Fradafiban

产品活性：Fradafiban 是一种非肽血小板糖蛋白 IIb/IIIa 复合体拮抗剂，其与人血小板 GP IIb/IIIa 复合体结合，K_d 值为 148 nM。

研究领域：Cytoskeleton

作用靶点：Integrin

In Vitro: Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a K_d value of 148 nM.

In Vivo: Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion.

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