Recombinant Metalloproteinase

The Matrix Metalloproteinase (MMP) and Tissue Inhibitor of Metalloproteinase (TIMP) Genes: Transcriptional and Posttranscriptional Regulation, Signal

(Table 1 ). The enzymatic activity of MMP family members is controlled by a group of inhibitor proteins known as the Tissue Inhibitors of Metalloproteinases (TIMPs), which consist of four family members (Table 2 ). Whereas all four TIMPs can inhibit

Expression of Tissue Inhibitor of Metalloproteinases by Recombinant Baculovirus-Infected Insect Cells Cultured in an Airlift Fermentor

The recombinant baculovirus expression system, developed in the laboratories of Summers (1 ) and Miller (2 ), has been widely used for the production of heterologous proteins (3 , 4 ). In this system, the gene to be expressed is cloned

Regulation of Angiostatin Mobilization by Tumor-Derived Matrix Metalloproteinase-2

. Our interest in this area stemmed from our discovery of angiostatin (1) , a 38 kDa internal fragment of plasminogen that is a specific inhibitor of capillary endothelial cell proliferation in vitro and angiogenesis in vivo. By inhibiting angiogenesis, angiostatin