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- 2025年08月15日
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文献和实验Secondary structure of prion mRNA
of structural elements in mRNA of prion protein From the EMBL data bank, 23 PrP mRNA sequences of the following species were available: three rodents (mouse, hamster, rat), two ruminants (cattle, sheep), the human and 17 non-human primates consisting
The pathogenesis of scrapie and other transmissible spongiform encephalopathies (TSEs) appears to be based on the posttranslational conversion of the host’s protease-sensitive prion protein (PrP-sen or PrPc ) to abnormal protease-resistant
Neuropathological Diagnosis of Human Prion Disease: PrP Immunocytochemical Techniques
in tissue sections. Since it is now known that CJD and related diseases are associated with accumulation in the brain of a protease-resistant protein known as prion protein (4 ), the demonstration of prion presence in suspected cases would represent
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