Anti-Human IgG, Gamma Heavy Ch

Production of Chimeric Heavy-Chain Antibodies

of camelid sdAb to human Fc. The cHCAb has a molecular size approximately half that of IgG (80 kDa vs. 150 kDa). Production is achieved through a transient expression with a human embryonic kidney (HEK) expression system, which can rapidly provide hundreds

重链结合蛋白(heavy-chain binding protein, Bip)

Bip是重链结合蛋白的简称,因为它能够同IgG抗体的重链结合而得名。Bip是一类分子伴侣,属于Hsp70家族,在内质网中有两个作用。 第一，Bip同进入内质网的未折叠蛋白质的疏水氨基酸结合，防止多肽链不正确地折叠和聚合。然后Bip同ATP结合并通过ATP的水解释放出结合的多肽。在多数情况下，释放出的多肽很快折叠，或者同别的亚基共同组装成完整的蛋白质。正确折叠和装配的蛋白质不会同Bip再结合，但是，如果蛋白质进行了不正确的折叠或错误的装配，Bip会马上同这种

Developing Anti-HER2/neu Single-Chain Fv Fragments from Phage Display Libraries

kDa IgG molecule is limited to 1 mm in 2-3 d (4 ). In contrast, smaller molecules such as 50 kDa Fab fragments exhibit faster movement through the tumor interstitium, on the order of 1 to 2 mm per day.