Neohesperidin dihydrochalcone新

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Neohesperidin dihydrochalcone

CAS No. : 20702-77-6

MCE 国际站：Neohesperidin dihydrochalcone

产品活性：Neohesperidin dihydrochalcone是一种糖苷查耳酮，作为低热量甜味剂添加到各种食品和饮料中。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species

In Vitro: Neohesperidin dihydrochalcone shows remarkable radical scavenging activity against stable radical and reactive oxygen species (ROS) in concentration dependent manner. Especially, neohesperidin dihydrochalcone is the most potent inhibitor of H₂O₂ and HOCl. Neohesperidin dihydrochalcone shows HOCl scavenging activity of 93.5% and H₂O₂ scavenging property of 73.5%. Neohesperidin dihydrochalcone shows extensive inhibitory effect especially on non-radical ROS H₂O₂ and HOCl with IC₅₀ values of 205.1, 25.5 μM. Neohesperidin dihydrochalcone is found to be an activator of porcine pancreatic alpha-amylase (PPA) with an IC₅₀ of 389 μM.

In Vivo: Neohesperidin dihydrochalcone administration results in significant reduction in activities of two useful markers of liver damage, AST and ALT. The relative levels of NF-κB, IL-6, IL-1β and TNF-α protein in the liver of PQ-treated mice are inhibited by neohesperidin dihydrochalcone. The embryotoxicity/teratogenicity of neohesperidin dihydrochalcone is examined in Wistar Crl:(WI)WU BR rats. No adverse effects are observed at neohesperidin dihydrochalcone levels of up to 5% of the diet, the highest dose level tested, at which the rats consumed about 3.3 g/kg body weight/day.

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