Neohesperidin新橙皮苷,13241-33-3

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Neohesperidin

CAS No. : 13241-33-3

MCE 国际站：Neohesperidin

产品活性：Neohesperidin是一种大量存在于柑橘属植物中的类黄酮化合物，具有抗氧化和抗炎作用的。

研究领域：Others

作用靶点：Others

In Vitro: Neohesperidin induces cell apoptosis in human breast adenocarcinoma MDA-MB-231 cells. The IC₅₀ values of neohesperidin at 24 and 48 h are 47.4±2.6 μM and 32.5±1.8 μM, respectively. The expressions of P53 and Bax in the neohesperidin-treated cells are significantly up-regulated, while that of Bcl-2 is down-regulated. Neohesperidin exhibits antioxidant activity (IC₅₀=22.31 μg/mL) in the DPPH radical-scavenging assay.

In Vivo: Neohesperidin (50 mg/kg) significantly inhibits 55.0% of HCl/ethanol-induced gastric lesions. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreases the volume of gastric secretion and gastric acid output, and increases the pH. Treatment of neohesperidin significantly decreases fasting glucose, serum glucose, and glycosylated serum protein (GSP) in mice. It significantly elevates oral glucose tolerance and insulin sensitivity and decreases insulin resistance in the diabetic mice. Neohesperidin significantly decreases serum triglycerides, total cholesterol, leptin level, and liver index in the mice.

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