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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
S-8527
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥412.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥400.0 |
| 规格： | 10 mg | 产品价格： | ￥560.0 |
| 规格： | 25 mg | 产品价格： | ￥1120.0 |
| 规格： | 50 mg | 产品价格： | ￥1800.0 |
| 规格： | 100 mg | 产品价格： | ￥2800.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Clinofibrate
CAS No. : 30299-08-2
MCE 国际站：Clinofibrate
产品活性：Clinofibrate (S-8527)是一种降血脂药和一种HMG-CoA还原酶抑制剂。
研究领域：Metabolic Enzyme/Protease | Autophagy
作用靶点：HMG-CoA Reductase (HMGCR) | Autophagy
In Vivo: Clinofibrate administration (50 and 100 mg/kg/day, p.o.) significantly inhibits the increase in plasma fibrinogen level as well as serum- and VLDL-LDL-lipids. Clinofibrate significantly decreases the high plasma cholesterol level of atherosclerotic rats, which is 823±256 mg/dl, or about ten times that of control rats (85±11 mg/dl). On treatment with clinofibrate, the cholesterol level is reduced most in the very low density lipoprotein (VLDL) fraction. In rats which are refed either a fat-free diet or a 5% fat diet after a 2-day fast. clinofibrate at 30 mg/kg results in reductions of serum and liver triglyceride levels. Oral ingestion of S-8527 to normal rats for 7 days lowers serum triglycerides and cholesterol by about 27% at 1 mg/kg and 20% at 3 mg/kg, respectively. S-8527 at 3 mg/kg decreases liver triglyceride concentration by about 20%.
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