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- MedChemExpress(MCE)
- 美国
- HY-101419
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
ML249
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
945128-26-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥501.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥300.0 |
| 规格： | 5 mg | 产品价格： | ￥720.0 |
| 规格： | 10 mg | 产品价格： | ￥1080.0 |
| 规格： | 25 mg | 产品价格： | ￥2160.0 |
| 规格： | 50 mg | 产品价格： | ￥3240.0 |
| 规格： | 100 mg | 产品价格： | ￥4860.0 |
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CYM-5541
CAS No. : 945128-26-7
MCE 国际站：CYM-5541
产品活性：CYM-5541 (ML249)是选择性的S1P3受体变构激动剂，EC50值在72至132 nM之间。
研究领域：GPCR/G Protein
作用靶点：LPL Receptor
In Vitro: CYM-5541 is a full agonist, able to reach the maximum level of ERK phosphorylation that is observed with S1P. CYM-5541 has an EC50 of between 72 and 132 nM and exhibits exquisite selectivity over other S1P receptor subtypes: S1P1 EC50>10 μM, S1P2 EC50>50 μM, S1P4 EC50>50 μM, and S1P5 EC50>25 μM. CYM-5541 also shows selectivity over a large panel of protein targets, with no significant activities, in the Ricerca profiling panel of 55 GPCRs, ion channels, and transporters. CYM-5541 allowed us to identify an allosteric site where F263 is a key gate-keeper residue for its affinity and efficacy. The novel allosteric hydrophobic pocket may account for the S1P3 selectivity of CYM-5541.
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