UK-371804,256477-09-5

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UK-371804

CAS No. : 256477-09-5

MCE 国际站：UK-371804

产品活性：UK-371804是尿嘧啶型纤溶酶原激活物 (uPA) 的抑制剂，K_i值为10 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：PAI-1

In Vitro: UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC₅₀=0.89 μM). UK-371804 has its excellent enzyme potency (K_i=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).

In Vivo: In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM.

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