Ubiquitin Isopeptidase Inhibit

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Ubiquitin Isopeptidase Inhibitor I, G5

CAS No. : 108477-18-5

MCE 国际站：Ubiquitin Isopeptidase Inhibitor I, G5

产品活性：Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303)是凋亡不依赖的半胱天冬酶和细胞凋亡的激活剂，对E1A和E1A/C9DN细胞的IC₅₀值分别为1.76和1.6 μM。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC₅₀s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

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