Biotinylated Human IL-4 Protein, Avi Tag (Avitag™)
库存:
In Stock
供应商:
ACROBiosystems
规格:
25ug
内毒素:
Less than 1.0 EU per μg by the LAL method.
纯度:
>95% as determined by SDS-PAGE.
活性:
Measured by its binding ability in a functional ELISA. Immobilized Human IL-4 R alpha, His Tag (Catalog # ILR-H5221) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-4, His Tag (Catalog # IL4-H82E0) with a linear range of 1.95-15.6 ng/mL.
产品背景:
Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.
产品描述:
This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 17.6 kDa. As a result of glycosylation, the protein migrates as 22 kDa under reducing (R) condition, and 21 kDa under non-reducing (NR) condition (SDS-PAGE).