BLU-554

BLU-554

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  • ¥500
  • 喀露蓝
  • 上海
  • CPDB0942
  • 2025年07月14日
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    上海喀露蓝科技技术有限公司
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    • 详细信息
    • 技术资料
    • 保质期：

      2年

    • 英文名：

      N-{3-[6-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinazolin-2-ylamino]-tetrahydro-pyran-4-yl}-acrylamide

    • 库存：

      现货 1mg-100g-1kg

    • 供应商：

      喀露蓝

    • 规格：

      98%min

    BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor. IC50 & Target: FGFR4[1] InVitro: Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR-4 gene. This protein is a member of the fibroblast growth factor receptor family, where amino acid sequence was highly conserved between members throughout evolution. FGFR family members 1-4 differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of the FGFR-4 gene encompasses 18 exons. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the Iglll domain of this protein varies between three alternate forms, as indicated for FGFR 1-3


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    BLU-554
    ¥500