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BLU-554

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  • ¥500
  • 喀露蓝
  • 上海
  • CPDB0942
  • 2025年07月14日
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    上海喀露蓝科技技术有限公司
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保质期：

      2年

    • 英文名：

      N-{3-[6-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinazolin-2-ylamino]-tetrahydro-pyran-4-yl}-acrylamide

    • 库存：

      现货 1mg-100g-1kg

    • 供应商：

      喀露蓝

    • 规格：

      98%min

    BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor. IC50 & Target: FGFR4[1] InVitro: Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR-4 gene. This protein is a member of the fibroblast growth factor receptor family, where amino acid sequence was highly conserved between members throughout evolution. FGFR family members 1-4 differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of the FGFR-4 gene encompasses 18 exons. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the Iglll domain of this protein varies between three alternate forms, as indicated for FGFR 1-3


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    图标文献和实验
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      following manufacturers protocol.In vitro transcribed RNA probes(using Bartel lab T7 polymerase):1-2ulDNA template (~100-500ng)5ul10 X T7 buffer1ul10mM ATP1ul10mM CTP1ul10mM GTP5ulalpha P32 UTP (800Ci/mmol) NEN cat# : BLU007X1ul0.25M DTT2.5ulT7 polymerase

    • 【求助】急需要一张PI3K/AKT途径信号图

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    • 　相关系数界值表－

      0.549 0.589 0.635 0.665 20 0.152 0.284 0.360 0.423 0.492 0.537 0.576 0.622 0.652 21 0.148 0.277 0.352 0.413 0.482 0.526 0.565 0.610 0.640 22 0.145 0.271 0.344 0.404 0.472 0.515 0.554 0.599 0.629 23 0.141 0.265 0.337 0.396 0.462 0.505 0.543 0.588 0.618 24

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    BLU-554
    ¥500