NCBI Gene Id: 6584
Swissprot Id: O76082
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAN00467
MCF7 Cells
Immunofluorescence analysis of MCF7 cell using SLC22A5 antibody. Blue: DAPI for nuclear staining.
Multiple Cell Lines
Western blot analysis of extracts of various cell lines, using SLC22A5 antibody.