NCBI Gene Id: 143686
Swissprot Id: P58005
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAN01166
Multiple Cell Types
Western blot analysis of extract of various cells, using SESN3 antibody.