NCBI Gene Id: 5684
Swissprot Id: P25788
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAN00319
MCF7 Cells
Immunofluorescence analysis of MCF7 cell using PSMA3 antibody. Blue: DAPI for nuclear staining.
U20S Cells
Immunofluorescence analysis of U2OS cell using PSMA3 antibody. Blue: DAPI for nuclear staining.
Multiple Cell Lines
Western blot analysis of extracts of various cell lines, using PSMA3 antibody.