NCBI Gene Id: 5607
Swissprot Id: Q13163
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAN02068
U20S Cells
Immunofluorescence analysis of U2OS cell using MAP2K5 antibody. Blue: DAPI for nuclear staining.
Multiple Cell Lines
Western blot analysis of extracts of various cell lines, using MAP2K5 antibody.