NCBI Gene Id: 3603
Swissprot Id: Q14005
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAN00516
U20S Cells
Immunofluorescence analysis of U2OS cell using IL16 antibody. Blue: DAPI for nuclear staining.
Multiple Cell Lines
Western blot analysis of extracts of various cell lines, using IL16 antibody.