NCBI Gene Id: 875
Swissprot Id: P35520
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAN00347
U20S Cells
Immunofluorescence analysis of U2OS cell using CBS antibody. Blue: DAPI for nuclear staining.
Mouse Kidney
Immunohistochemistry of paraffin-embedded mouse kidney using CBS antibody at dilution of 1:100 (x400 lens).
Multiple Cell Lines
Western blot analysis of extracts of various cell lines, using CBS antibody.