For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
形态:
Liquid, 1 mg/mL provided in PBS containing 0.02% sodium azide.
亚型:
IgG
免疫原:
SESTRIN2 antibody was raised against a 19 amino acid peptide near the center of human SESTRIN2.
规格:
100 ug
NCBI Gene Id: 83667
Swissprot Id: P58004
SESTRIN2, also known as Hi95, is a member of the sestrin family of PA26-related proteins and is induced following DNA damage or oxidative stress (1). SESTRIN2 and the related protein SESTRIN1 interact with the NRF2 suppressor KEAP1, the autophagy substrate p62 and the ubiquitin ligase RBX1 to protect cells against oxidative stress by activating NRF2 and promoting the p62-dependent autophagic degradation of KEAP1 (2). SESTRIN2 also negatively regulates TOR signaling by activating AMP-activated protein kinase (AMPK) and TSC2 phosphorylation (3), thereby protecting cells against energetic stress-induced death (4). - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAPB01969
Kidney tissue lysate
Western blot analysis of SESTRIN2 in mouse kidney tissue lysate with SESTRIN2 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.