Store at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
形态:
Liquid
亚型:
Rabbit IgG
规格:
100 ul
NCBI Gene Id: 4194
Swissprot Id: O15151
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminal and a RING finger domain at the C-terminal, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAB20479
Human Colon Carcinoma Cells
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using MDM4 (Phospho-Ser367) antibody (OAAB20479).
Human HeLa Cells
Western blot analysis of extracts from HeLa cells, treated with calyculinA (50ng/ml, 30mins), using MDM4 (Phospho-Ser367) antibody (OAAB20479).