Add 0.2ml of distilled water will yield a concentration of 500ug/ml. Store at -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
A synthetic peptide corresponding to a sequence at the N-terminus of human FLI1(54-73aa QQEWINQPVRVNVKREYDHM), identical to the related rat and mouse sequences.
规格:
100 ug
NCBI Gene Id: 2313
Swissprot Id: Q01543
Friend leukemia integration 1 transcription factor, also known as Transcription factor ERGB or Proto-oncogene Fli-1 is a protein that in humans is encoded by the human FLI1 gene. The fli1 protooncogene encodes a member of the ETS family of winged helix-turn-helix transcription factors. This gene is mapped to 11q24.3. Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias. The constitutive activation of fli-1 in erythroblasts leads to a dramatic shift in the Epo/Epo-R signal transduction pathway, blocking erythroid differentiation, activating the Ras pathway, and resulting in massive Epo-independent proliferation of erythroblasts. These results suggest that Fli-1 overexpression in erythroblasts alters their responsiveness to Epo and triggers abnormal proliferation by switching the signaling event(s) associated with terminal differentiation to proliferation. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OABB01342
Human Tonsil Tissue
Anti-FLI1 antibody, OABB01342, IHC(P) IHC(P): Human Tonsil Tissue
Rat Spleen Tissue
Anti-FLI1 antibody, OABB01342, IHC(P) IHC(P): Rat Spleen Tissue
JURKAT Cell Lysate, RAJI Cell Lysate
Anti-FLI1 antibody, OABB01342, Western blotting Lane 1: JURKAT Cell Lysate Lane 2: RAJI Cell Lysate