NCBI Gene Id: 9874
Swissprot Id: Q9UKI8
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAB19796
Hela whole cell lysates, C6 whole cell lysates
All lanes: Anti-TLK1 Antibody at 1: 1000 dilution Lane 1: Hela whole cell lysates Lane 2: C6 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size: 87 kDa Blocking/Dilution buffer: 5% NFDM/TBST.