Shipped at 4C, Store at -20C (Avoid repeated freeze/thaw cycles).
形态:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 53% glycerol
规格:
100 ul
NCBI Gene Id: 1154
Swissprot Id: Q9NSE2
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAB19581
Hela cell line, human liver, human kidney tissue lysate
Western blot analysis of lysates from Hela cell line, human liver, human kidney tissue lysate (from left to right), using CISH Antibody (A1-1587). A1-1587 was diluted at 1: 500 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1: 10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.