KLH conjugated synthetic phosphopeptide derived from human Mcl 1 around the phosphorylation site of Ser159/Thr163. Immunogen range: 140-190/350.
规格:
100 ul
NCBI Gene Id: 4170
Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OABF01204
Rat brain
Formalin-fixed and paraffin embedded rat brain labeled with Anti-Phospho-Mcl1 (Ser159/Thr163) Polyclonal Antibody, Unconjugated (OABF01204) at 1:200, followed by conjugation to the secondary antibody and DAB staining