KLH conjugated synthetic phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr463
规格:
100 ul
NCBI Gene Id: 2260; 2263
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OABF01554
Human cervical carcinoma
Formalin-fixed and paraffin embedded human cervical carcinoma labeled with Anti-Phospho-FGFR1 FGFR2 (Tyr463) Polyclonal Antibody, Unconjugated (OABF01554) at 1:200 followed by conjugation to the secondary antibody and DAB staining