KLH conjugated synthetic peptide derived from human Socs 1
规格:
100 ul
NCBI Gene Id: 8651
Swissprot Id: O15524
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OABF00055
Human colon cancer
Formalin-fixed and paraffin embedded human colon cancer labeled with Anti-Socs1Polyclonal Antibody (OABF00055), Unconjugated at 1:300, followed by conjugation to the secondary antibody and DAB staining