The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C to 8C for three month without detectable loss of activity. Avoid repeated freezing thawing cycles.
亚型:
Rabbit IgG
免疫原:
A synthetic peptide surrounding of - LGSPV- of Human CDC25B protein WITHOUTthe phosphorylation site at Serine 42.
规格:
100 ug
NCBI Gene Id: 994
Swissprot Id: P30305
Three homologues of CDC25 called CDC25A/B/C Cdc25 tyrosine phosphatases positively regulate the cell cycle by activating cyclin-dependent kinase/cyclin complexes CDK1 (CDC2). Dephosphorylation of threonine 14 and tyrosine 15 of CDK1 by CDC25 phosphatases is a key step in the activation of the CDK1-cycline B protein kinase. Of the three mammalian Cdc25 isoforms, Cdc25A is phosphorylated by genotoxic stress-activated Chk1 or Chk2, which triggers its SCFbeta-TrCP-mediated degradation. CDC25B is degraded by the proteasome. CDK1-cyclin A phosphorylation targets CDC25B for degradation and this might be an important component of cell cycle regulation at the G2/M transition. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAI00504
Hela
WB:The cell lysate derived from Hela was immunoblotted by Rabbit anti CDC25B (Paired S42) (Cat#OAAI00504) at 1:500. An immunoreactive band is observed ~65kDa.