Anti-Collagen I alpha 1 Telopeptide Sequence (OAPC00095)
靶点:
COL1A1
应用范围:
WB, IHC
宿主:
Rabbit
适应物种:
Human, Mouse, Rat, Sheep
克隆性:
Polyclonal
保存条件:
Store at -20C; stable for at least one year.
形态:
Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
免疫原:
Peptide from the human collagen I alpha 1 telopeptide sequence.
规格:
100 ul
NCBI Gene Id: 1277
Swissprot Id: P02452
Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the fist 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005). - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAPC00095
Mouse lung
Immunostaining of formaldehyde-fixed fibrotic mouse lung tissue. The antibody recognizes mature collagen I (red) that has formed fibrils in the extracellular matrix.
Rat lung
Western blot of rat lung lysate showing specific immunolabeling of the ~ 140k collagen protein.