Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles.
形态:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
亚型:
Rabbit Ig
免疫原:
This ALS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1248~1277 amino acids from the C-terminal region of human ALS2.
规格:
400ul
NCBI Gene Id: 57679
Swissprot Id: Q96Q42
ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in its gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis.
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human brain
ALS2 Antibody (C-term) (RB18853) IHC analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ALS2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Mouse Lung
Western blot analysis of ALS2 antibody (C-term) in mouse lung tissue lysates (35ug/lane). ALS2 (arrow) was detected using the purified Pab.