Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
克隆性:
Polyclonal
保存条件:
-20C
形态:
Lyophilized
免疫原:
The immunogen is a synthetic peptide directed towards the C terminal region of human MANF
规格:
50 ug
NCBI Gene Id: 7873
Swissprot Id: A8K878
MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of MANF gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet_lyophilized.php?sku=ARP59608_P050