NCBI Gene Id: 3172; 3174
Swissprot Id: P41235
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OKAG00464
HepG2 Nuclear Extract
HNF4/ DNA-Binding ELISA Kit detects active HNF4/ in HepG2 Nuclear Extract. The HepG2 cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract.