Histone H2AX Antibody - C-terminal region (OARD00077)
靶点:
H2AFX
应用范围:
WB, ELISA
宿主:
Rabbit
适应物种:
Human
标记物:
Unconjugated
克隆性:
Monoclonal
保存条件:
For short term, store at 2-8C. For extended storage, aliquot and store at -20C. Expiration: 2 Years from date of receipt.
形态:
Liquid
亚型:
IgG
免疫原:
A peptide corresponding to the C-terminal of human Histone H2AX
规格:
100 ul
NCBI Gene Id: 3014
Swissprot Id: P16104
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OARD00077
A375, HEK293, HeLa, SK-MEL-2 whole cell lysates
Western Blot of A375, HEK293, HeLa and SK-MEL-2 whole cell lysates, using OARD00077 at 0.5 ug/mL, showed endogenous Histone H2AX in A375, HEK293, HeLa and SK-MEL-2 cells.