The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C to 8C for three month without detectable loss of activity. Avoid repeated freezing thawing cycles.
亚型:
Mouse IgG1
免疫原:
The synthetic peptide corresponding to SH2 domain of c-Abl protein.
规格:
100 ug
NCBI Gene Id: 25
Swissprot Id: P00519
The c-Abl proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. It is activated by certain DNA-damaging agents and regulates induction of the stress-activated c-Jun N-terminal protein kinase (SAPK). In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the geneRation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAI00281
Human Placenta
IHC: The human Placenta stained with Mouse anti c -Abl monoclonal antibody (Cat#OAAI00281) at 1:100. (Note: formalin -fixed, paraffin -embedded sections need 15 minutes heat -induced epitope retrieval in 10 mM citrate buffer, pH 6.0, and 30 minutes incubation at room temperature with the primary antibody.
Hela
Western Blot: The whole cell lysate derived from HELA was separated in 10% SDS -PAGE, transferred onto NC membrane, and immunoblotted by Mouse anti- Abl (Cat#OAAI00281) antibody at 1:500. An immunoreactive band around 120 kDa was observed.