Store at 4C, for long term storage, store at -20C.
亚型:
IgG1
免疫原:
Purified recombinant fragment of human AKT1 expressed in E. Coli.
规格:
0.1ml
NCBI Gene Id: 207
Swissprot Id: P31749
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAD00344
NIH/3T3, Hela, COS7, Jurkat
western blot analysis using AKT1 mouse mAb against NIH/3T3 (1)? Hela (2)?COS7 (3) and Jurkat (4) cell lysate.