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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant Dog Telomerase reverse transcriptase protein (1-308AA)
- 亚型:
IgG
- 形态:
Liquid
- 保存条件:
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性:
Polyclonal
- 标记物:
FITC
- 适应物种:
Dog
- 保质期:
6个月
- 抗原来源:
Dog
- 目录编号:
Q6A548
- 级别:
优
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 宿主:
Rabbit
- 应用范围:
/
- 浓度:
>95%,Protein G purified
- 靶点:
TERT
- 抗体英文名:
TERT Antibody, FITC conjugated
- 抗体名:
TERT antibody;Telomerase reverse transcriptase antibody;EC 2.7.7.49 antibody;Telomerase catalytic subunit antibody
- 规格:
100μg/50μg
| 规格: | 100μg | 产品价格: | ¥1320.0 |
|---|---|---|---|
| 规格: | 50μg | 产品价格: | ¥880.0 |
保存缓冲液
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
功能
Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins.风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验单抗主要是鼠单抗、兔单抗,多抗主要是兔多抗、山羊多抗等,其他种属来源抗体较少。不建议纠结于单抗好还是多抗好,能做出实验的抗体就是好抗体。 在选择上一般建议实验种属和抗体种属亲缘性越远越好,不宜同源。抗体不同种属会要影响接下来二抗的选配。特别是在免疫荧光双标实验中,需要在区别于实验种属的基础上,区分开两个指标的抗体种属来源,以便于二抗区别识别。 3. 关于性价比的选择 抗体的品质高低最终还是需要通过实验结果来呈现的,但是在选择抗体之前我们并无法准确判断抗体的效果
catabolite repression|分解代谢物阻抑,分解代谢产物阻遏 catalase|过氧化氢酶 catalytic active site|催化活性位 catalytic activity|催化活性 catalytic antibody|催化性抗体,具有催化活性的抗体 catalytic constant|催化常数[符号Kcat] catalytic core|催化核心 catalytic
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