TP53INP1抗体TP53INP1兔多抗抗体Tumor p
rotein p53-inducible nuclear protein 1 antibody抗体TP53INP1 Antibody抗体- ￥440 - 1320
- CUSABIO
- CN
- CSB-PA822174LA01HU
- 2025年07月13日
- ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant Human Tumor protein p53-inducible nuclear protein 1 protein (138-205AA)
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
Q96A56
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200
- 浓度：
>95%,Protein G purified
- 靶点：
TP53INP1
- 抗体英文名：
TP53INP1 Antibody
- 抗体名：
Tumor protein p53-inducible nuclear protein 1 antibody
- 规格：
100μg/50μg/20μg
| 规格： | 100μg | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 50μg | 产品价格： | ￥880.0 |
| 规格： | 20μg | 产品价格： | ￥440.0 |
保存缓冲液
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
功能
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Induction of p53 Protein as a Marker for Ionizing Radiation Exposure In Vivo
to individual cells, thus a critical balance must be achieved when using radiation as a form of anticancer treatment to ensure tumor cell death with minimal side effects to normal tissue and organ function. Morphological damage following nonlethal exposure
via the ubiquitinproteasome system (UPS). Key proteins such as transcription factors, nuclear receptors, cyclins, cyclin-dependent kinase inhibitors, p53, and NF-κB are regulated by this pathway. Thus, the UPS has been implicated to play a role in multiple cellular events
Detection of Protein‐Protein Interactions by Coprecipitation
that can be coupled to a solid?phase matrix. An associated protein is detected by separating the precipitated proteins by SDS?PAGE and immunoblotting with a second antibody that recognizes the putative associated protein. Keywords
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