TDP1抗体TDP1兔多抗抗体Tyrosyl-DNA pho

保存缓冲液

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

功能

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3\'-phosphodiester bond, giving rise to DNA with a free 3\' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3\'-phosphoglycolates on protruding 3\' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3\'exonuclease activity and can remove a single nucleoside from the 3\'end of DNA and RNA molecules with 3\'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3\'phosphate.