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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant Human NEDD4 family-interacting protein 1 protein (2-116AA)
- 亚型:
IgG
- 形态:
Liquid
- 保存条件:
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性:
Polyclonal
- 标记物:
HRP
- 适应物种:
Human
- 保质期:
6个月
- 抗原来源:
Homo sapiens (Human)
- 目录编号:
Q9BT67
- 级别:
优
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 宿主:
Rabbit
- 应用范围:
ELISA
- 浓度:
>95%,Protein G purified
- 靶点:
NDFIP1
- 抗体英文名:
NDFIP1 Antibody, HRP conjugated
- 抗体名:
Putative NFKB and MAPK-activating protein
- 规格:
100μg/50μg
| 规格: | 100μg | 产品价格: | ¥1320.0 |
|---|---|---|---|
| 规格: | 50μg | 产品价格: | ¥880.0 |
保存缓冲液
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
功能
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity (PubMed:19706893). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (PubMed:20534535). Enhances the ubiquitination of BRAT1 mediated by E3 ubiquitin-protein ligases: NEDD4, NEDD4L and ITCH, and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046).风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验祝贺〖雅裕睿安〗成为Signalway Antibody(SAB)独家
SAB(Signalway antibody ) 是一家汇聚了多名专家和学者的新型高科技生物公司,其研发和生产的抗体包括了数百种磷酸化 / 非磷酸化抗体 ( 可以提供同一位点的磷酸化 / 非磷酸化的成对抗体 ) ,为神经科学、细胞信号转导 (Akt pathway , Jat/Sat pathway , MAPK pathway , NF-Kappa B pathway 等 ) 、癌症 / 凋亡、细胞周期、染色质 / 转录、细胞骨架通道、胰岛素 / 葡萄糖、核受体 / 膜受体
和改进,由于这种方法采用放射性核素标记,应用范围受到一定限制,为了进一步提高检测的灵敏度和操作的安全性,进入90年代又陆续发明了各种酶标记法和化学发光法的竞争性ELISA检测试剂盒,这一类检测方法的根本原理都是基于抗体抗原的免疫反应,所有这些试剂盒中采用的抗体全部是兔抗血清或者是经过特异亲和提纯之后的抗cAMP或cGMP的兔多抗,毫无疑问,兔多抗在约四十年的cAMP,cGMP定量检测中做出了巨大贡献,但同时它也有着明显的缺陷: 1,兔多抗对cAMP,cGMP的特异性不高,会
[129] 梅懋华.消化道生理学与临床.北京:人民卫生出版社,1990 [130] 李悦山 ,董伟华, 梁仲培.机能实验学.北京:北京大学医学医学出版社,2005 [131] 王清勇,冯世俊,刘作屏.生理学、病理生理学、药理学实验指导.北京:人民卫生出版社,2005 [132] Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse
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