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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Synthesized peptide derived from Internal of Human PDK1.
- 亚型:
/
- 形态:
Liquid
- 保存条件:
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性:
Polyclonal
- 标记物:
/
- 适应物种:
Human,Mouse,Rat
- 保质期:
6个月
- 抗原来源:
Homo sapiens (Human)
- 目录编号:
Q15118
- 级别:
优
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 宿主:
Rabbit
- 应用范围:
ELISA,WB;WB:1:500-1:3000
- 浓度:
>95%,The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 靶点:
PDK1
- 抗体英文名:
PDK1 Antibody
- 抗体名:
/
- 规格:
100μl
保存缓冲液
/功能
Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.Gudi R., J. Biol. Chem. 270:28989-28994(1995).
Ota T., Nat. Genet. 36:40-45(2004).
Burkard T.R., BMC Syst. Biol. 5:17-17(2011).
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文献和实验该产品被引用文献
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文献支持
PDK1抗体PDK1兔多抗抗体/抗体PDK1 Antibody抗体
¥2024





