- ￥2200 - 9800
- MedChemExpress(MCE)
- 美国
- HY-16293
- 2025年07月16日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
PM01183; LY-01017
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
497871-47-3
- 规格：
100 μg/1 mg/5 mg
| 规格： | 100 μg | 产品价格： | ￥2200.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥6500.0 |
| 规格： | 5 mg | 产品价格： | ￥9800.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Lurbinectedin
CAS No. : 497871-47-3
MCE 国际站：Lurbinectedin
产品活性：Lurbinectedin (PM01183) 是一种 DNA 小沟共价粘合剂，具有高效的抗肿瘤活性; 抑制RMG1和RMG2的IC50值分别为1.25和1.16 nM。
研究领域：Cell Cycle/DNA Damage
作用靶点：DNA Alkylator/Crosslinker | DNA/RNA Synthesis
In Vitro: PM01183 is a new synthetic tetrahydroisoquinoline alkaloid that is currently in phase I clinical development for the treatment of solid tumours. PM01183–DNA adducts in living cells give rise to double-strand breaks, triggering S-phase accumulation and apoptosis. The potent cytotoxic activity of PM01183 is ascertained in a 23-cell line panel with a mean GI50 value of 2.7 nM. Lurbinectedin exhibits significant antitumor activity toward chemosensitive and chemoresistant human ovarian clear cell carcinoma (CCC) cells in vitro.
In Vivo: Mouse CCC cell xenografts reveals that lurbinectedin significantly inhibits tumor growth. Lurbinectedin plus SN-38 results in a significant synergistic effect. In four murine xenograft models of human cancer, PM01183 inhibits tumour growth significantly with no weight loss of treated animals. Single lurbinectedin or NSC 119875-combined therapies are effective in treating NSC 119875-sensitive and NSC 119875-resistant preclinical ovarian tumor models. The strongest synergistic effect is observed for combined treatments, especially in NSC 119875-resistant tumors. Lurbinectedin tumor growth inhibition is associated with reduced proliferation, increased rate of aberrant mitosis, and subsequent induced apoptosis.
相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | Bioactive Compound Library Plus | Cisplatin | Cycloheximide | Actinomycin D | Oxaliplatin | Gemcitabine | Temozolomide | Cyclophosphamide | Carboplatin | Bleomycin sulfate | Mitomycin C | Cytarabine | Methotrexate | ART558 | Streptozotocin | Anisomycin | Fludarabine | Thymidine | Hydroxyurea | Remdesivir | Daunorubicin hydrochloride | Brequinar | Capecitabine | Branaplam | N-Nitroso-N-methylurea | α-Amanitin | CX-5461 | Folic acid | Urolithin A
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
