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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
T5601640
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
924473-59-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥428.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥233.0 |
| 规格： | 5 mg | 产品价格： | ￥500.0 |
| 规格： | 10 mg | 产品价格： | ￥850.0 |
| 规格： | 25 mg | 产品价格： | ￥1700.0 |
| 规格： | 50 mg | 产品价格： | ￥2700.0 |
| 规格： | 100 mg | 产品价格： | ￥4200.0 |
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T56-LIMKi
CAS No. : 924473-59-6
MCE 国际站：T56-LIMKi
产品活性：T56-LIMKi是选择性的LIMK2抑制剂。抑制Panc-1细胞生长的IC50值为35.2 μM。
研究领域：Cell Cycle/DNA Damage
作用靶点：LIM Kinase (LIMK)
In Vitro: T56-LIMKi efficiently inhibits the growth of ST88-14, U87, Panc-1 cells, A549 lung cancer cells with IC50 values of 18.3, 7.4, 35.2 and 90 μM, respectively. T56-LIMKi decreases phosphorylated cofilin (p-cofilin) levels and thus inhibits growth of several cancerous cell lines, including those of pancreatic cancer, glioma and schwannoma. It blocks the phosphorylation of cofilin which leads to actin severance and inhibition of tumor cell migration, tumor cell growth, and anchorage-independent colony formation in soft agar. T56-LIMKi (10-50 μM) reduces p-cofilin in a dose-dependent manner in NF1−/−MEFs with an IC50 of 30 μM. Notably, the inhibitor does not affect the amounts of total cofil. 50μM T56-LIMKi causes a statistically significant reduction in the number of cells exhibiting stress fibers.
In Vivo: T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage in vivo. Mice treated with T56-LIMKi (60 mg/kg) shows a significant decrease in tumor volume compared to control.
相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Targeted Diversity Library | Highly Selective Inhibitors Library | BMS-5 | SM1-71 | BMS-3 | TH-257 | SR7826 | RSS0680 | DB0614 | DB1113 | R-10015 | CRT0105950 | DD-03-156 | LIMK1 inhibitor BMS-4 | TH470 | 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide | Aurora/LIM kinase-IN-1 | CRT 0105446 | Curcolonol | LIMK-IN-1 | S3 Fragment
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