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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
1640282-31-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1766.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥614.0 |
| 规格： | 5 mg | 产品价格： | ￥1713.0 |
| 规格： | 10 mg | 产品价格： | ￥2475.0 |
| 规格： | 25 mg | 产品价格： | ￥4088.0 |
| 规格： | 50 mg | 产品价格： | ￥5563.0 |
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I-CBP112
CAS No. : 1640282-31-0
MCE 国际站：I-CBP112
产品活性：I-CBP112是一种特异性和有效的乙酰-赖氨酸竞争性蛋白-蛋白相互作用抑制剂，抑制 CBP/p300 溴结构域，增强 p300 的乙酰化作用。
研究领域：Epigenetics
作用靶点：Histone Acetyltransferase | Epigenetic Reader Domain
In Vitro: I-CBP112 significantly enhances acetylation by p300 at the histone H3K18 and H3K23 sites. I-CBP112 stimulated H3K18ac by ~3-fold, I-CBP112 induced enhances acetylation of these same sites by CBP as well as at H4K5. The EC50’s of activation of I-CBP112 on p300- and CBP-mediated H3K18 acetylation are ~2 μM. Exposure of human and mouse leukemic cell lines to I-CBP112 results in substantially impaired colony formation and induces cellular differentiation without significant cytotoxicity. Exposure of the BioMAP primary cell panel to I-CBP112 results in a unique response on cytokine and marker protein expression.
In Vivo: I-CBP112 significantly reduces the leukemia-initiating potential of mLL-AF9+ AmL cells in a dose-dependent manner in vitro and in vivo. The synergistic effects of I-CBP112 and current standard therapy (doxorubicin) as well as emerging treatment strategies (BET inhibition) provide new opportunities for combinatorial treatment of leukemia and potentially other cancers.
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Preparing 48-Well Plate Feeders[Baylor College of Medicine]
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v468.chapter 1 经典 Wnt/b-Catenin 信号通路 （英文完整版）
/TLE proteins and recruiting an array of coactivator proteinsincluding CBP, TBP, BRG-1, Bcl9, Legless, Mediator, and Hyrax. This ensures efficient activation of Tcf target genes suchas c-Myc, which instruct the cell to actively proliferate and remain
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