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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1628317-18-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥794.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥373.0 |
| 规格： | 5 mg | 产品价格： | ￥745.0 |
| 规格： | 10 mg | 产品价格： | ￥1178.0 |
| 规格： | 25 mg | 产品价格： | ￥2038.0 |
| 规格： | 50 mg | 产品价格： | ￥2913.0 |
| 规格： | 100 mg | 产品价格： | ￥4013.0 |
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MI-463
CAS No. : 1628317-18-9
MCE 国际站：MI-463
产品活性：MI-463是高效，有口服活性的menin-mLL相互作用的小分子抑制剂。
研究领域：Epigenetics
作用靶点：Epigenetic Reader Domain
In Vitro: MI-463 can reach the target protein in mammalian cells and effectively inhibit the menin-mLL-AF9 interaction at sub-micromolar concentrations. Treatment of murine bone marrow cells (BMC) transformed with the mLL-AF9 oncogene with MI-463 results in substantial growth inhibition, with GI50 of 0.23 μM.
In Vivo: MI-463 achieves high level in peripheral blood following a single intravenous or oral dose, while also showing high oral bioavailability (45%). Pharmacologic inhibition of the menin-mLL interaction substantially delays progression of mLL leukemia in murine models through on-target activity without causing toxicity. MI-463 induces strong inhibition of tumor growth with once daily intraperitoneal (i.p.) administration. The expression of mLL fusion protein target genes, HOXA9 and MEIS1, are significant reduced upon treatment with MI-463. 20 days treatment of MV4;11 xenograft recipient mice with MI-463 also results in a substantial delay in leukemia progression as manifested by a marked decrease in the bioluminescence level which is associated with a significant decrease in the population of leukemic cells in the peripheral blood, spleen and bone marrow samples.
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文献和实验”和“-as”来命名，但现在已经取消了这种命名方式。 注意：miRBase 18.0对miRNA(microRNA)成熟体的名称进行了大量的修改，很多带“*”的miRNA(microRNA)都变成了“-5p”或“-3p”。当然，新名称下面对应有其原来的名称。 案例请见：http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 2) miRNA编号及名称(以动物miRNA为例) miRBase记录了miRNA(microRNA
许可产品。13. 点击下一步。14. 点击下一步。15. 输入代码：9MQT8R78RQBWEXN3WRG7CEC2WCO6TOREVH6CBAI8TI58MI2QM22IKP6V9L8DHS6T2MOFL5MPNSEXTH4SYI24JOU3WO，点击下一步。16. 点击下一步。17. 点击完成。18. 在开始菜单所有程序中找到 IBM SPSS 24 软件图标，然后鼠标右击发送到桌面快捷方式。19. 在电子邮件地址处随意输入一个邮箱即可，点击开始试用。20. 点击勾选 「以后不在显示此对话
Assessment of Neurogenesis and White Matter Regeneration
to compensate for and recover neural functions that were destroyed by central nervous system disorders. In fact, since Liu et al. (J Neurosci 18:7768–7778, 1998) first showed that ischemia stimulates neurogenesis in the SGZ of the DG using gerbil forebrain
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