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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
(E)-Cardamomin; (E)-Alpinetin chalcone
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
19309-14-9
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥270.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥246.0 |
| 规格： | 10 mg | 产品价格： | ￥400.0 |
| 规格： | 25 mg | 产品价格： | ￥700.0 |
| 规格： | 50 mg | 产品价格： | ￥1050.0 |
| 规格： | 100 mg | 产品价格： | ￥1575.0 |
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(E)-Cardamonin
CAS No. : 19309-14-9
MCE 国际站：(E)-Cardamonin
产品活性：(E)-Cardamonin ((E)-Cardamomin) 是新颖的hTRPA1阳离子通道拮抗剂，IC50值为454 nM。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Apoptosis
作用靶点：TRP Channel | Apoptosis
In Vitro: (E)-Cardamonin ((E)-Cardamomin) selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. (E)-Cardamonin ((E)-Cardamomin) does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. (E)-Cardamonin ((E)-Cardamomin) suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.
In Vivo: (E)-Cardamonin ((E)-Cardamomin) (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia.
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