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- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1405-41-0
- 规格：
500 mg/1 g/5 g
| 规格： | 500 mg | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 1 g | 产品价格： | ￥770.0 |
| 规格： | 5 g | 产品价格： | ￥2100.0 |
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Gentamicin sulfate
CAS No. : 1405-41-0
MCE 国际站：Gentamicin sulfate
产品活性：Gentamicin sulfate 是一种具有口服活性的氨基糖苷类抗生素，抑制革兰氏阳性菌和革兰氏阴性细菌的生长并可抑制组织培养中的多种支原体菌株。Gentamicin sulfate 抑制 DNase I 活性的 IC50 值为 0.57 mM。
研究领域：Anti-infection
作用靶点：Bacterial | Antibiotic
In Vitro: Gentamicin is a more effective in vitro bacterial inhibitor than combined penicillin-streptomycin, is nontoxic to tissue culture monolayers, and does not inhibit virus replication.
Gentamicin has been used with success as an additive in commercial mycology media to inhibit growth of bacteria and has been shown to be bactericidal for a wider range of organisms (Pseudomonas aeruginosa, Proteus sp., and Streptococcus faecalis) than penicillin and streptomycin.
Gentamicin does not interfere with the production of cytopathic effect by certain echoviruses and polioviruses in tissue culture, is nontoxic to Rhesus monkey kidney, HeLa, and human amnion cells, and is stable at autoclave temperatures.
Gentamicin is produced by various species of the genus Micromonospora.
Gentamicin C1a binds in the major groove of the A-site of the RNA.
In Vivo: Gentamicin (oral and injectable forms) exhibits effective antibacterial activity against Yersinia pestis as demonstrated in a mouse infection model.
Gentamicin (0.27 g/kg) shows a significant reduction of bacteria on the foreign body in mouse.
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文献和实验Metabolic Labeling with Sulfate
of proteins make it possible to determine where a protein normally resides or to follow its transport through the cell. One such modification is addition of sulfate either to tyrosine residues or to carbohydrate side chains. Labeling studies with [35 S
Ammonium Sulfate Binding Assay for Cells
1. Resuspend cells (vegetative or developed) in phosphate buffer at 1 x 10 8 /ml . 2. Add 50 ul cells to 50 ul 20 nM 3H-cAMP in 5-10 mM DTT (for background binding, add same amount of hot cAMP plus 10 uM cold cAMP) in 1.5 ml eppendorf tube
在哺乳动物真皮中发现的一种粘多糖。在真皮中，于成熟的胶原纤维丰富的层中，以蛋白多糖即以与蛋白质相结合的（蛋白硫酸皮肤素）形式而存在。因此胶原分子是按一定的空间排列集成，并由桥键组成纤维构造，而蛋白硫酸皮肤素具有重要作用。除皮肤以外，也可从大动脉、脐带、腱、心脏瓣膜、肝脏和半月瓣等分离出来，而在鼻软骨和骨端软骨中并不存在。化学构造如图所示是 L-艾杜糖醛酸和 N-乙酰半乳糖胺 -4-硫酸所形成的二糖单位的重复结构而为其主体，但糖醛酸的一部分为艾杜糖
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