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| 规格： | 5 mg | 产品价格： | ￥700.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥880.0 |
| 规格： | 25 mg | 产品价格： | ￥1760.0 |
| 规格： | 50 mg | 产品价格： | ￥2816.0 |
| 规格： | 100 mg | 产品价格： | ￥4500.0 |
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PD-166866
CAS No. : 192705-79-6
MCE 国际站：PD-166866
产品活性：PD166866是选择性的FGFR1酪氨酸激酶抑制剂，IC50值为52.4 nM。
研究领域：Protein Tyrosine Kinase/RTK | Autophagy
In Vitro: PD 166866 inhibits human full-length FGFR-1 tyrosine kinase with an IC50 value of 52.4 nM and is characterized as an ATP competitive inhibitor of the FGFR-1. PD 166866 is a potent inhibitor of FGFR autophosphorylation in NIH 3T3 cells expressing endogenous FGFR-1 and in L6 cells overexpressing the human FGFR-1 tyrosine kinase. PD 166866 also inhibits bFGF-induced tyrosine phosphorylation of the 44- and 42-kDa (ERK 1/2) mitogen-activated protein kinase isoforms in L6 cells. Daily exposure of PD 166866 to L6 cells at concentrations from 1 to 100 nM results in a concentration-related inhibition of bFGF-stimulated cell growth for 8 consecutive days with an IC50 value of 24 nM.
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