- 询价
- PEPROTECH
- 美国
- 200-36A
- 2025年07月15日
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- 详细信息
- 技术资料
- 保存条件：
-20℃
- 保质期：
1年以上
- 英文名：
Recombinant Human IL-36alpha (IL-1F6)
- 库存：
大量
- 供应商：
PeproTech(派普泰克)
- CAS号：
无
Recombinant Human IL-36α (IL-1F6)
Catalog Number:
200-36A
Synonyms:
Interleukin-36α, IL36A, Interleukin-1 family member 6 (IL-1F6), FIL1ε (FIL1E), Interleukin-1ε (IL1E)
Description:
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8), and γ (IL-1F9). IL-36α is highly expressed in psoriatic plaques, as are IL-36β and IL-36γ, and is the only IL-1 family member found to be expressed by T-cells, as well as monocytes and B-cells. Primarily found in skin and lymphoid tissues, IL-36α is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36α signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36α also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36α is a 17.2 kDa protein containing 154 amino acid residues.
AA Sequence:
MKIDTPQQGS IQDINHRVWV LQDQTLIAVP RKDRMSPVTI ALISCRHVET LEKDRGNPIY LGLNGLNLCL MCAKVGDQPT LQLKEKDIMD LYNQPEPVKS FLFYHSQSGR NSTFESVAFP GWFIAVSSEG GCPLILTQEL GKANTTDFGL TMLF
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Measured by its ability to induce IL-8 secretion by A431 human epidermoid carcinoma cells.
Research Interests:
Country of Origin:
USA
Research Use Only. Not for use in diagn
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PeproTech重组人IL-36alpha(IL-1F6) 100ug
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