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- Bioss
- bs-1363P
- 2026年10月10日
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500ug
| 产品编号 | bs-1363P |
| 英文名称 | Iba-1/ AIF-1 Antibody Blocking Peptide |
| 中文名称 | 离子钙接头蛋白封闭多肽 |
| 英文别名 | AIF 1; AIF1; AIF1 protein; IBa1; iba-1; IBa 1; allograft inflammatory factor 1; Allograft inflammatory factor 1 splice variant G; balloon angioplasty responsive transcription; BART 1; G1; G1 putative splice variant of allograft inflamatory factor 1; IBA 1; IBA1; interferon gamma responsive transcript; Ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule; IRT 1; IRT1; Microglia response factor; MRF1; Protein G1. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Binding Proteins |
| 亚基 | Homodimer (Potential). Monomer. Interacts with LCP1. |
| 亚细胞定位 | Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. |
| 组织特异性 | Detected in T-lymphocytes and peripheral blood mononuclear cells. |
| 相似性 | Contains 2 EF-hand domains. |
| 功能 | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Allograft Inflammatory Factor-1 (AIF1)or ionized calcium-binding adaptor molecule 1 (Iba1) is expressed selectively in microglia/macrophages and is a Ca2+-binding peptide produced by activated monocytes and microglial cells. It has been suggested that AIF1 expression is associated with chronic inflammatory processes. AIF1 is expressed by activated monocytes and might participate in a variety of pathogenic processes in the mammalian brain and in chronic transplant rejection. It has been shown to be expressed early and persistently in chronically rejecting cardiac allografts but not in cardiac syngrafts and host hearts. |
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文献和实验该产品被引用文献
[IF=6.2] Junbo Chen. et al. 2′-Fucosyllactose Alleviates Metabolic Hypertension in Mice via Gut Microbiota Modulation and Involvement of the LPS/TLR4 Signaling. J AGR FOOD CHEM. 2026 Apr IF Mouse
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AIF1 | IBA1 Ab Blocking Peptide(bs-1363P)-500ug
￥880
