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- P0005
- 2025年10月17日
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5mg/10mg
| 规格： | 5mg | 产品价格： | ￥200.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥300.0 |
| 产品编号 | P0005 |
| 英文名称 | Bovine Insulin |
| 中文名称 | 牛胰岛素 |
| 英文别名 | ILPR; INS; Insulin A chain; Insulin B chain; Insulin A chain; Insulin precursor; IRDN; Proinsulin; Proinsulin precursor; IDDM2; INS_BOVIN; MODY10; Bovine Insulin |
| 理论分子量 | 5.8 |
| 研究领域 | Cardiovascular > Atherosclerosis > Diabetes associated Metabolism > Types of disease > Diabetes Metabolism > Types of disease > Heart disease Metabolism > Types of disease > Obesity Neuroscience > Neurology process > Metabolism Signal Transduction > Growth Factors/Hormones > Insulin / Insulin-like |
| 亚基 | Heterodimer of a B chain and an A chain linked by two disulfide bonds. |
| 亚细胞定位 | Secreted. |
| 相似性 | Belongs to the insulin family. |
| 功能 | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma. |
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文献和实验[IF={{ 3.191 }}] {Wenjing Sun. et al. A homogeneous enzyme-free ratiometric immunoassay for the determination of C-peptide. ANAL BIOCHEM. 2022 Sep;:114899} {Other} {Other}
[IF={{ 10.3 }}] {Jingming Ren. et al. Amelioration of gamma irradiation-induced salivary gland damage in mice using melatonin. J PINEAL RES. 2023 Jun;:} {Other} {}
结晶牛胰岛素（crystallized bovine insulin）
牛胰岛素的晶状体。牛胰岛素是牛胰脏中胰岛β-细胞所分泌的一种调节糖代谢的蛋白质激素。其一级结构1955年由英国桑格（S.Sanger）测定。我国中科院生化研究所、北大化学系及中科院有机化学研究所通力合作，于1959年开始工作、1965年9月获得了用人工方法合成的、有生物活性的结晶牛胰岛素，实现了世界上首次人工合成蛋白质的壮举。
Culture of BEND Cells (Bovine Endometrial Cells)
Hams F-12 (N6760) Powdered MEM D-valine modification (M7395) Fetal bovine serum (F4135) Horse serum (H1138) Antibiotic-antimycotic (ABAM) (A9909) D-valine (V1255) Insulin (I5500) Preparation 1. Place 1000 ml of double distilled water
Secretion of Recombinant Human Insulin-Like Growth Factor I (IGF-I)
for therapeutic proteins that need to be administered on a daily basis for prolonged periods or if dosage requirements are very high. The use of Pichia pastoris as a recombinant expression host strain can be an excellent choice for such situations. P. pastoris
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